Imunofan is an immunostimulating drug with hepatoprotective, detoxifying, and antioxidant effects.

The active substance of the immunomodulator Imunofan is arginyl-alpha-aspartyl-lysyl-valyl-tyrosyl-arginine - a hexapeptide, a synthetic derivative of thymopoietin.

In this article, we will look at why doctors prescribe Imunofan, including instructions for use, analogues and prices for this. medicine in pharmacies. Real REVIEWS of people who have already used Imunofan can be read in the comments.

Composition and form of release

There are three forms of release of the drug: injection solution, Imunofan suppositories for rectal use and nasal metered spray.

• The active ingredient is imunofan. The concentration in the solution for injection is 50 mcg per ampoule, in the spray - 50 mcg per dose, in one suppository - 100 mcg.

pharmachologic effect: the drug belongs to the group of immunomodulatory drugs.

What helps Imunofan?

Imunofan is used in complex therapy immunodeficiency states. It is prescribed for the treatment of the following diseases:

1. Herpes virus type 1 and 2, toxoplasma, cytomegalovirus, chlamydia, cryptospores;
2. Chronic hepatitis C and B;
3. HIV infection and AIDS;
4. Tumors that are caused by HPV;
5. Brucellosis;
6. Psoriasis;
7. Diphtheria;
8. Rheumatoid arthritis;
9. Bacterial endocarditis;
10. Long-term non-healing wounds, burns.

Pharmacological properties

Candles Imunofan have a pronounced immunostimulating, detoxifying, hepatoprotective effect. Therapeutic action drug is based on recovery metabolic processes in the body, stimulation of protective forces, increasing the body's resistance to infections.

• After the introduction of the suppository into the rectum, the therapeutic effect develops after 2 hours - this is called the fast phase. During this period, the drug shows its detoxification function. If a patient has liver damage of toxic or infectious origin, then the use of Imunofan contributes to a decrease in bilirubin and the level of liver enzymes, a decrease in the phenomenon of cytolysis.
• For 2-3 days of action of the drug, they speak of the middle phase. During this period, the death of intracellular organisms occurs, which is noted against the background of activation of phagocytosis. In this regard, patients may experience exacerbation of chronic foci of inflammation.
• The therapeutic effect from 7 days to 4 months is called the slow phase. During this period, the drug shows its immunomodulatory effect. There is a regulation of humoral and cellular immunity, the formation of IgA, an increase in the number of specific antibodies is noted.

Imunofan suppresses the drug resistance of tumor cells by increasing their sensitivity to the effects of cytostatic drugs.

Instructions for use

The solution is intended for s / c or / m injections, the drug is prescribed in courses, the daily (single) dose is 50 mcg. The course of treatment depends on the clinical indications and the age of the patient:

• In the treatment of patients with oncological diseases in the scheme of radical combined treatment (chemoradiation therapy and surgery): before chemo radiation therapy- 1 ml 1 time / day every other day (per course - 3-5 injections); before surgery - 1 ml 1 time / day every other day (per course - 2-3 injections, followed by continuation of the course with the same interval). In patients with a widespread tumor process (III-IV stage) of various localization in terms of complex or symptomatic therapy - 1 ml 1 time / day every other day, per course - 5-7 ml, with a break of 20 days and a course repeated 2-3 times.
• Cytomegalovirus and herpetic infection, cryptosporidiosis, toxoplasmosis, pneumocystosis, chlamydia: 15-20 injections or suppositories, or 1 spray dose in each nasal passage 2 times a day for 10-15 days, repetition of courses is possible after a break of 2-4 weeks ;
• For chlamydia, herpes and other similar infections - 1 dose of nasal spray 2 times a day, lasting 10-15 days, or 1 ml as an injection into the muscle or subcutaneously, for 15-20 days. It is recommended to repeat the course of treatment in 2-4 weeks.
• In the treatment of bacteria carriers, 1 ml of Imunofan is administered once a day, with an interval of 4 days. A total of 3-5 ml is injected.
• III-IV degree burns with signs of toxemia and septicotoxemia, septic endocarditis, purulent-septic complications after surgical operations, long-term non-healing wounds of the extremities: 7-10 injections or suppositories, in severe cases, treatment is recommended to continue up to 20 days;
• In the treatment of rheumatoid arthritis, 1 ml of Imunofan is taken once a day, with an interval of 4 days. In total, 8-10 ml is injected.

Animals are prescribed for the prevention of infectious diseases, as well as for the treatment of viral and bacterial infections. For prevention, it is administered once or once every ten days in the presence of an epidemic. For the purpose of treatment, the drug is administered in 1 dose every other day once a day. Treatment lasts eight days, during which time the animal receives 4 doses of the drug. A detailed treatment plan is written by the veterinarian who treats the animal.

Contraindications

Imunofan (shots, suppositories and nasal drops) should not be taken to treat rheumatoid arthritis and other diseases in such cases:

1. Pregnancy;
2. lactation period;
3. The patient's age is up to two years;
4. Individual intolerance active substance medicines.

Side effects

Injections, suppositories and spray are well tolerated by the patient. In very rare cases, the patient may experience the following side effects:

1. Dizziness;
2. Pain at the injection site (in therapy for rheumatoid arthritis);
3. Sleep deterioration;
4. Weakness.

Analogues

The drug Imunofan has no structural analogues for the active substance.

Imunofan's analogues in the formological group are Affinoleukin, Actinolysate, Bestim, Broncho-Vaxom, Broncho-munal P, Vilozen, Preparation KK Cat's Claw, Rexod, Polyoxidonium, Poludan, Methyluracil, Ribomunil.

Attention: the use of analogues must be agreed with the attending physician.

Dosage form:  solution for intramuscular and subcutaneous administration Compound:

BUTactive substance: imunofan 0.005 g, Excipients (glycine 0.5 g, sodium chloride 0.9 g, water for injection up to 100 ml).

Description: Colorless transparent liquid. Pharmacotherapeutic group:Immunomodulating agent ATX:  

L.03.A.X Other immunostimulants

Pharmacodynamics:

The drug has immunoregulatory, detoxifying,hepatoprotective action and causes inactivation free radical and peroxide compounds. The pharmacological action is based on the achievement of three main effects: correction of the immune system, restoration of the balance of the body's oxidative-antioxidant reaction, and inhibition of multidrug resistance mediated by proteins of the cell's transmembrane transport pump.

Pharmacokinetics:

The action of the drug begins to develop within 2-3 hours after administration (fast phase) and lasts up to 4 months (medium and slow phases).

During the fast phase (starts after 2-3 hours, duration - up to 2-3 days), the detoxification effect is manifested primarily: the antioxidant defense of the body is enhanced by stimulating the production of ceruloplasmin, lactoferrin, catalase activity; the drug normalizes the level of lipid peroxidation, inhibits the breakdown of cell membrane phospholipids and the synthesis of arachidonic acid, followed by a decrease in the concentration of cholesterol in the blood and the production of inflammatory mediators. With toxic and infectious liver damage, the drug prevents cytolysis, reduces the activity of transaminases and the concentration of bilirubin in the blood serum.

During the middle phase (begins after 2-3 days, duration - up to 7-10 days) there is an increase in the reactions of phagocytosis and the death of intracellular bacteria and viruses.

During the slow phase (begins on the 7-10th day, duration up to 4 months), the immunoregulatory effect of Imunofan is manifested - the restoration of disturbed indicators of cellular and humoral immunity. During this period, there is a normalization of the immunoregulatory index, there is an increase in the production of specific antibodies. The influence of Imunofan on the production of specific antiviral and antibacterial antibodies is equivalent to the action of some therapeutic vaccines. Unlike the latter, the drug does not significant influence for the production of reaginic antibodies of the class IgE (immunoglobulin E) and does not increase the hypersensitivity reactionimmediate type. The drug stimulates the formation IgA (immunoglobulin A) with its congenital deficiency.

Imunofan effectively suppresses multidrug resistance of tumor cells and increases their sensitivity to the action of cytostatic drugs.

Indications:

In adultsas an adjuvant for vaccination against bacterial and viral infections.

Preventionexacerbation of chronic infections inflammatory diseases of various etiologies occurring against the background of immunodeficiency in adults and children over 2 years of age: chronic viral hepatitis, brucellosis.

Preventiondevelopment of toxicosis atchildren older than 2 years sincemalignant diseases of hematopoietic and lymphoid tissue against the background of a course of chemoradiotherapy.

Treatmentas part of the complex therapy of secondary immunodeficiency and toxic conditions caused by the following diseases.

In adults:

- in the complex therapy of oncological diseases in the scheme of radical combined treatment (chemoradiotherapy and surgery), in complex or symptomatic therapy in patients with advanced tumor process(III - IV stages) of different localization;

- in the complex therapy of chronic viral hepatitis, chronic brucellosis;

- in the complex therapy of HIV infection, opportunistic infections (cytomegalovirus, herpetic infections, toxoplasmosis, chlamydia, pneumocystosis, cryptosporidiosis);

- in the treatment of burns III-IV degree with the phenomena of toxemia, septicotoxemia, in surgical patients with septic endocarditis, cholecystopancreatitis, long-term non-healing wounds limbs, purulent-septic complications;

- in the complex therapy of broncho-obstructive syndrome, rheumatoid arthritis, psoriasis.

In adults and children over 2 years of age:

- in the complex therapy of inflammatory eye diseases;

- in the treatment of diphtheria, diphtheria bacteriocarrier.

In children older than 2 years:

- in the complex therapy of papillomatosis of the larynx and oropharynx.

Contraindications:

Hypersensitivity to the components of the drug. Childhood up to 2 years.

Pregnancy and lactation:

Due to insufficient knowledge during pregnancy and during breastfeeding used only if the intended benefit to the mother outweighs the potential risk to the fetus and child.

Dosage and administration:

Imunofan is used subcutaneously or intramuscularly in a single dose of 50 mcg. The maximum daily dose is 50 mcg. The drug is used in courses, depending on the purpose of the application and the nature of the disease.

In adults.

As an adjuvant when vaccinated against bacterial and viral infections - once at a dose of 50 mcg intramuscularly or subcutaneously on the day of vaccination.

AT complex treatment cancer patients:

- in the scheme of radical combined treatment - once a day, a course of 8-10 injections before chemoradiotherapy and surgery, followed by continuation of the course throughout the entire period of treatment.

- in patients with a widespread tumor process - once daily, with a course of 8-10 injections, with a break of 15-20 days and repeating the course during the entire subsequent period of treatment.

In the complex treatment of patients with chronic viral hepatitis and brucellosis:

In the complex therapy of HIV infection and opportunistic infections:

once a day, the course of treatment is 15-20 injections. If necessary, it is possible to repeat the course in 2-4 weeks.

In surgical patients, in the treatment of burns III-IV degrees with the phenomena of toxemia, septicotoxemia, in surgical patients with septic endocarditis, cholecystopancreatitis, long-term non-healing wounds of the extremities, purulent-septic complications:

- once a day, the course of treatment is 7-10 injections, if necessary, the course of the drug can be extended to 20 injections.

At broncho-obstructive syndrome, rheumatoid arthritis:

- once every 3 days, the course of treatment is 8-10 injections, if necessary, the course of treatment can be extended to 20 injections.

In the complex therapy of psoriasis:

- once a day, the course of treatment is 15-20 injections.

In adults and children over 2 years of age.

In the complex therapy of inflammatory eye diseases:

- with damage to the anterior parts of the eye (keratitis, keratouveitis) once a day, the course of treatment is 7-10 injections;

- with damage mainly to the posterior parts of the eye (peripheral, posterior uveitis, retinovasculitis) and generalized inflammatory processes once a day, the course of treatment is 15-20 injections.

In the treatment of diphtheria:

- once a day, the course of treatment is 8-10 injections. With diphtheria bacteriocarrier - once every 3 days, per course - 3-5 injections.

In the complex therapy of children with papillomatosis of the larynx and oropharynx in children older than 2 years:

- once a day, the course of treatment is 10 injections.

For prevention:

exacerbations of chronic viral hepatitis and chronic brucellosis in adults and children older than 2 years

daily once a course of 15-20 injections, repeated preventive courses are recommended every 2-3 months;

development of toxicosis in children older than 2 years with malignant diseases of the hematopoietic and lymphoid tissue

- once a day, the course of treatment is 10-20 injections, during and after the course of chemoradiotherapy.

Side effects:

Individual intolerance is possible. Possible allergic reactions.

Overdose:

Cases of drug overdose are not known.

Interaction:

AT clinical practice there are no cases of interaction of Imunofan with other drugs.

The action of the drug does not depend on the production of prostaglandin E 2, in this regard, the appointment of Imunofan is possible in combination with anti-inflammatory steroid and non-steroid drugs.

Special instructions:

As a result of the activation of phagocytosis, a short-term exacerbation of foci of chronic inflammation, supported by the persistence of viral or bacterial antigens, is possible.

Influence on the ability to drive transport. cf. and fur.:

The drug does not affect the ability to drive vehicles, mechanisms.

Release form / dosage:

Solution for intramuscular and subcutaneous administration.

Package: Ampoules containing 50 μg of the drug in 1.0 ml of solution. 5 ampoules with instructions are placed in a cardboard pack, or 5 ampoules are placed in a blister pack, 1 blister pack with instructions is placed in a cardboard pack. Storage conditions:

In a place protected from light at a temperature of 2°C to 10°C. Keep out of the reach of children.

Best before date:

3 years. Do not use the drug after the expiration date indicated on the package.

Conditions for dispensing from pharmacies: On prescription Registration number: R N000106/02 Date of registration: 18.08.2010 / 03.12.2015 Expiration date: Perpetual Registration certificate holder: BIONOX NPP, OOO Russia Manufacturer:   Information update date:   06.11.2017 Illustrated Instructions

In this article, you can read the instructions for use medicinal product Imunofan. Reviews of site visitors - consumers of this medicine, as well as opinions of doctors of specialists on the use of Imunofan in their practice are presented. A big request to actively add your reviews about the drug: did the medicine help or not help get rid of the disease, what complications and side effects were observed, perhaps not declared by the manufacturer in the annotation. Analogues of Imunofan in the presence of existing structural analogues. Use for the treatment of herpes, chlamydia, psoriasis in adults, children, as well as during pregnancy and lactation. The composition of the drug.

Imunofan- has an immunoregulatory, detoxifying, hepatoprotective effect and causes inactivation of free radical and peroxide compounds. The pharmacological action is based on achieving 3 main effects: correcting the immune system, restoring the balance of the body's oxidative-antioxidant reaction, and inhibiting multidrug resistance mediated by proteins of the cell's transmembrane transport pump.

The action of the drug begins to develop within 2-3 hours (fast phase) and lasts up to 4 months (medium and slow phases).

During the fast phase (duration - up to 2-3 days), first of all, the detoxification effect is manifested - the antioxidant defense of the body is enhanced by stimulating the production of ceruloplasmin, lactoferrin, catalase activity; the drug normalizes lipid peroxidation, inhibits the breakdown of cell membrane phospholipids and the synthesis of arachidonic acid, followed by a decrease in blood cholesterol levels and the production of inflammatory mediators. With toxic and infectious liver damage, the drug prevents cytolysis, reduces the activity of transaminases and the level of bilirubin in the blood serum.

During the middle phase (begins after 2-3 days, duration - up to 7-10 days) there is an increase in the reactions of phagocytosis and the death of intracellular bacteria and viruses.

During the slow phase (begins to develop for 7-10 days, duration up to 4 months), the immunoregulatory effect of the drug is manifested - the restoration of disturbed indicators of cellular and humoral immunity. During this period, there is a restoration of the immunoregulatory index, there is an increase in the production of specific antibodies. The effect of the drug on the production of specific antiviral and antibacterial antibodies is equivalent to the effect of therapeutic vaccines. Unlike the latter, the drug does not significantly affect the production of reaginic IgE antibodies and does not enhance the immediate hypersensitivity reaction. Imunofan stimulates the formation of IgA in its congenital deficiency.

Imunofan effectively suppresses multidrug resistance of tumor cells and increases their sensitivity to the action of chemotherapeutic drugs.

Compound

Arginyl-alpha-aspartyl-lysyl-valyl-tyrosyl-arginine + excipients.

Indications

Prevention and treatment of immunodeficiency states of various etiologies in children and adults:

• combination therapy of tumors;
• papillomatosis of the larynx and oropharynx in children;
• opportunistic infections (cytomegalovirus and herpetic infection, toxoplasmosis, chlamydia, pneumocystosis, cryptosporidiosis);
• complex therapy of HIV infection;
• chronic viral hepatitis;
• chronic brucellosis;
• diphtheria (including bacteriocarrier);
• burns;
• septic endocarditis;
• long-term non-healing wounds;
• purulent-septic complications;
• broncho-obstructive syndrome;
• cholecystopancreatitis;
• rheumatoid arthritis;
• psoriasis.

As an adjuvant in vaccination against bacterial and viral infections in adults.

Release form

Spray nasal dosed.

Candles rectal 100 mcg.

Solution for intramuscular and subcutaneous injection No. 5 and No. 10 (injections in ampoules for injection).

Other forms of release, such as tablets, do not exist.

Instructions for use and method of use

Spray

Intranasally. When using the bottle should be held vertically, spray up. Remove the protective cap from the atomizer. Before the first use, fill the dosing pump by pressing the wide rim of the sprayer 3-4 times. Insert the nebulizer into the nasal passage vertical position heads. Press the wide rim of the atomizer once until it stops. One dose of the drug contains 50 mcg of imunofan. The daily dose should not exceed 200 mcg.

In the complex therapy of acute and chronic infectious and inflammatory diseases, accompanied by symptoms of intoxication and immunodeficiency, Imunofan is prescribed 1 dose (50 mcg) in each nasal passage 2 times a day, daily for 10-15 days.

With opportunistic infections (cytomegalovirus and herpes infection, toxoplasmosis, chlamydia, pneumocystosis, cryptosporidiosis): 1 dose (50 mcg) in each nasal passage 2 times a day, daily, course of treatment 10-15 days. If necessary, it is possible to repeat the course in 2-4 weeks.

In chronic viral hepatitis and chronic brucellosis: 1 dose (50 mcg) in each nasal passage 1 time per day, daily, course of treatment 10-15 days, to prevent relapse, repeat courses should be carried out after 4-6 months.

In the treatment regimen for patients with HIV infection: 1 dose (50 mcg) in each nasal passage 1 time per day, daily, for 10-15 days. If necessary, it is possible to repeat the course in 2-4 weeks.

In the treatment of cancer patients in the regimen of radical combined treatment (chemoradiotherapy and surgery): 1 dose (50 mcg) in each nasal passage 1 time per day, daily, for 8-10 days before chemoradiotherapy and surgery, followed by continuation of the course for throughout the entire period of treatment.

In patients with a common tumor process (stages 3-4) of various localization in terms of complex or symptomatic therapy: 1 dose (50 mcg) in each nasal passage 1 time per day, daily, for 8-10 days. If necessary, and the presence of pronounced symptoms of toxicosis, it is recommended to repeat the course.

Candles

Rectally. Single and daily dose - 100 mcg (1 suppository).

In the treatment of cancer patients in the scheme of radical combined treatment (chemoradiation therapy and surgery): once, daily, a course of treatment of 8-10 suppositories before chemoradiotherapy and surgery, followed by continuation of the course throughout the entire period of treatment.

In patients with a widespread tumor process (stages 3-4) of various localization in the form of complex or symptomatic therapy: once, daily, a course of treatment of 8-10 suppositories, with a break of 15-20 days and repetition of courses during the entire period of subsequent treatment.

In children with a malignant disease of the hematopoietic or lymphoid tissue: 1 time per day, daily, the course of treatment is 10-20 suppositories. The appointment of the drug should be carried out during the entire course of chemoradiotherapy and after the end of the course to prevent the development of toxicosis.

In the complex therapy of children with papillomatosis of the larynx and oropharynx: 1 time per day, daily, the course of treatment is 10 suppositories.

With opportunistic infections (cytomegalovirus and herpetic infection, toxoplasmosis, chlamydia, pneumocystosis, cryptosporidiosis): 1 time per day, daily, course of treatment 10 suppositories.

In the complex therapy of HIV infection: 1 time per day, daily, the course of treatment is 15-20 suppositories. If necessary, repeat courses should be carried out in 2-4 weeks.

In chronic viral hepatitis and chronic brucellosis: 1 time per day, daily, course of treatment 15-20 suppositories, to prevent relapse, repeat courses should be carried out after 2-3 months.

With diphtheria: 1 time per day, the course of treatment is 8-10 suppositories. With diphtheria bacteriocarrier - 1 time in 3 days - 3-5 suppositories.

In the treatment of burns of 3-4 degrees with symptoms of toxemia, septicotoxemia, in surgical patients with septic endocarditis, long-term non-healing wounds of the extremities, purulent-septic complications: 1 time per day, daily, the course of treatment is 7-10 suppositories, if necessary, the course of the drug should be continued up to 20 suppositories.

With broncho-obstructive syndrome, cholecystopancreatitis, rheumatoid arthritis: 1 time in 3 days, the course of treatment is 8-10 suppositories, if necessary, the course should be continued up to 20 suppositories with the same interval.

In the treatment of psoriasis: 1 time per day, daily, the course of treatment is 15-20 suppositories.

In adults in the scheme of vaccination - once a day of vaccination.

Side effect

• individual intolerance.

Contraindications

• children's age up to 2 years;
• pregnancy and lactation for injection form drug;
• increased sensitivity.

Use during pregnancy and lactation

Solution for intramuscular and subcutaneous administration and rectal suppositories are contraindicated in pregnancy complicated by Rhesus conflict.

Due to insufficient knowledge, nasal spray should be used with caution during pregnancy and lactation.

Use in children

Contraindicated in children under 2 years of age.

special instructions

As a result of the activation of phagocytosis, a short-term exacerbation of foci of chronic inflammation, supported by the persistence of viral or bacterial antigens, is possible.

drug interaction

Increases the efficiency of other types drug therapy: The use of Imunofan helps to overcome resistance to glucocorticosteroid (GCS) therapy. The appointment of imunofan is possible in combination with corticosteroids and non-steroidal anti-inflammatory drugs (NSAIDs).

Analogues of the drug Imunofan

The drug Imunofan has no structural analogues for the active substance.

Analogues for pharmacological group immunomodulators:

• Actinolysate;
• Aktipol;
• Alkimer;
• Anaferon;
• Anaferon for children;
• Arbidol;
• Arpetolid;
• Arpeflu;
• Affinoleukin;
• Baktisporin;
• Bestim;
• Broncho-Vaxom;
• Broncho-munal;
• Vilozen;
• Wobenzym;
• Galavit;
• Gepon;
• Glutoxim;
• Groprinosin;
• Desoxinate;
• Derinat;
• Dr. Theiss;
• Zadaksin;
• Imiquimod;
• Immunal;
• Immunomax;
• Immunorm;
• Imudon;
• Imunorix;
• IRS 19;
• Yodantipyrin;
• Likopid;
• Myelopid;
• Milife;
• Molixan;
• Sodium deoxyribonucleate;
• Sodium nucleinate;
• Neuroferon;
• Neovastat;
• Optinat;
• ORVItol NP;
• Panagen;
• Pyrogenal;
• Polyoxidonium;
• Posterisan;
• Posterized forte;
• Profetal;
• Respitan;
• Ribomunil;
• Rhinital;
• Ruzam;
• Splenin;
• Sporobacterin;
• Stemokin;
• Stimforte;
• Superlymph;
• Taktivin;
• Timalin;
• Thymogen;
• Thymusamine;
• Trekrezan;
• Tubosan;
• Uro Wax;
• Ferrovir;
• Phlogenzyme;
• Helixor;
• Exalb;
• Epifamin;
• Erbisol;
• Ergoferon;
• Estifan;
• Echinacea;
• Echinocor.

In the absence of analogues of the drug for the active substance, you can follow the links below to the diseases that the corresponding drug helps with and see the available analogues for the therapeutic effect.

A drug Imunofan has a regulatory effect on immune system, also affects the oxidative-antioxidant system of the body, improves the detoxification function, and has a hepatoprotective effect.
The action of the drug begins after 2-3 hours, the full effect develops after 4 months. Conventionally, the action of the drug can be divided into three phases:
1. Fast phase (begins 2-3 hours after taking the drug and lasts up to 3 days). The action of Imunofan is associated with its effect on the detoxification function, normalization of lipid peroxidation, suppression of the synthesis of arachidonic acid and inflammation markers. In case of liver damage of infectious or toxic origin, the phenomena of cytolysis decrease, the level of liver enzymes and bilirubin decreases.
2. The middle phase (begins 3 days after taking the drug and lasts up to 10 days).
During the middle phase, phagocytosis is activated and intracellular microorganisms die, as a result of which foci of chronic inflammation may be exacerbated.
3. Slow phase (beginning on the 10th day, lasts up to 4 months). At this stage, Imunofan promotes the formation of IgA, the regulation of cellular and humoral immunity, and increases the amount of specific antibodies. The drug is well combined with anti-inflammatory drugs (NSAIDs and steroids).

Indications for use

Immunodeficiencies of various origins, both in adults and in children:
- opportunistic infections: herpes virus type 1 and 2, cytomegalovirus, toxoplasma, cryptospores, chlamydia.
- in the complex therapy of chronic hepatitis B and C.
- in the complex therapy of HIV infection and AIDS;
- treatment of tumors caused by HPV;
- psoriasis;
- diphtheria;
- brucellosis;
- bacterial endocarditis;
- rheumatoid arthritis;
- for the treatment of burns and long-term non-healing wounds;
- as an adjuvant for vaccination in adults;
- as an element of combination therapy in cancer patients.

Mode of application

Imunofan administered subcutaneously or intramuscularly, 1 ml once a day.
For the treatment of cancer patients, the drug is prescribed 1 ml once a day, every other day, before chemotherapy or radiation therapy, a course of 3-5 injections is necessary, before surgical treatment a course of 2-3 injections is required. For oncological diseases of stage III-IV, the following scheme is recommended: 1 ml once a day, every other day, a course of treatment of 5-7 injections, then another 2-3 such courses, with a break of 20 days.
For the treatment of opportunistic infections, 1 ml once a day, with an interval of three days. The course of treatment is 10-15 ml.
For the treatment of brucellosis and chronic viral hepatitis, 1 ml once a day, with an interval of 4 days. The course of treatment is 8-10 ml.
For the treatment of diphtheria, 1 ml once a day, every day. The course of treatment is 8-10 ml. For the treatment of bacteria carriers, 1 ml once a day, with an interval of 4 days. The course of treatment is 3-5 ml.
For the treatment of patients with endocarditis, burns and long-term non-healing wounds, 1 ml once a day. The course of treatment is 7-20 ml.
For the treatment of rheumatoid arthritis, 1 ml once a day, with an interval of 4 days. The course of treatment is 8-10 ml (up to 20 ml).
For the treatment of patients with psoriasis, the drug is prescribed 1 ml once a day, every other day. Course 8-10 injections.
As an adjuvant, 1 ml once, on the day of vaccination.

Side effects

Usually Imunofan tolerated without side effects, in rare cases, allergic phenomena are possible.

Contraindications

:
A drug Imunofan contraindicated in pregnancy, which occurs with a conflict on the Rh factor.
Children's age up to 24 months.

Pregnancy

:
It is possible to use the drug Imunofan during pregnancy, in the absence of a conflict on the Rh factor.

Interaction with other drugs

During application imunofana there were no cases of adverse interactions with other drugs.

Storage conditions

Store ampoules for 2 years in a dry, dark place.

Release form

Solution 0.005% 1 ml, intended for subcutaneous or intramuscular injection, 5 ampoules per pack.

Compound

:
Each ampoule contains 50 mcg imunofana.

main parameters

Name:	IMUNOFAN
ATX code:	L03 -

Imunofan is an immunomodulatory drug with immunoregulatory, hepatoprotective and detoxifying effects. Active substance: Arginyl-alpha-aspartyl-lysyl-valyl-tyrosyl-arginine.

Pharmacological action is based on the achievement of 3 main effects:

1. Correction of the immune system;
2. Restoring the balance of the oxidative-antioxidant reaction of the body;
3. Inhibition of multidrug resistance mediated by proteins of the transmembrane transport pump of the cell.

The action of Imunofan begins within 2-3 hours (fast phase) and lasts up to 4 months (medium and slow phases).

During the fast phase (duration - up to 2-3 days), first of all, the detoxification effect is manifested - the antioxidant defense of the body is enhanced by stimulating the production of ceruloplasmin, lactoferrin, and catalase activity.

Imunofan normalizes lipid peroxidation, inhibits the breakdown of cell membrane phospholipids and the synthesis of arachidonic acid, followed by a decrease in blood cholesterol levels and the production of inflammatory mediators.

The middle phase begins its development on the third day after taking the drug and lasts up to ten days. During this period, the death of intracellular organisms occurs, which is noted against the background of activation of phagocytosis. In this regard, patients may experience exacerbation of chronic foci of inflammation.

The slow phase begins on the tenth day after taking the drug and can last up to four months. During this period, the drug shows its immunomodulatory effect. There is a regulation of humoral and cellular immunity, the formation of IgA, an increase in the number of specific antibodies is noted.

Indications for use

What helps Imunofan? According to the instructions, the drug is prescribed in the following cases:

• opportunistic infections: toxoplasma, chlamydia, herpes virus of the first and second type, cryptospores, cytomegalovirus;
• complex therapy of HIV and AIDS;
• complex therapy of chronic hepatitis B and C;
• combined therapy of oncological diseases;
• diphtheria;
• bacterial endocarditis;
• psoriasis;
• rheumatoid arthritis;
• brucellosis;
• treatment of burns and long-term non-healing wounds.

Instructions for use Imunofan, dosage

Solution for injection (injections) Imunofan is used subcutaneously or intramuscularly in a single dose of 50 mcg. The maximum daily dose is 50 mcg. The drug is used in courses, depending on the purpose of the application and the nature of the disease.

In adults, as an adjuvant for vaccination against bacterial and viral infections - once at a dose of 50 mcg intramuscularly or subcutaneously on the day of vaccination.

In the complex treatment of cancer patients:

• in the scheme of radical combined treatment - once a day, a course of 8-10 injections before chemoradiotherapy and surgery, followed by continuation of the course throughout the entire period of treatment.
• in patients with a widespread tumor process - once a day, a course of 8-10 injections, with a break of 15-20 days and repeating the course during the entire subsequent period of treatment.

According to the instructions, Imunofan is used in the complex treatment of patients with chronic viral hepatitis and brucellosis once a day, the course of treatment is 15-20 injections.

In the complex therapy of HIV infection and opportunistic infections - once a day, the course of treatment is 15-20 injections. If necessary, it is possible to repeat the course in 2-4 weeks.

In surgical patients, in the treatment of III-IV degree burns with symptoms of toxemia, septicotoxemia, in surgical patients with septic endocarditis, cholecystopancreatitis, long-term non-healing wounds of the extremities, purulent-septic complications - once a day, the course of treatment is 7-10 injections of Imunofan, if necessary, a course may be extended up to 20 injections.

With broncho-obstructive syndrome, rheumatoid arthritis - once every 3 days, the course of treatment is 8-10 injections, if necessary, the course of treatment can be extended to 20 injections.

In the complex therapy of psoriasis, Imunofan is used once a day, the course of treatment is 15-20 injections.

Instructions for candles Imunofan

Suppositories are intended for introduction into the rectum 1 time per day.

For the treatment of oncological neoplasms as part of therapy with chemotherapy drugs, 1 suppository \ 1 time per day for 10 days is prescribed. If necessary, treatment is extended for the entire period of chemotherapy or radiation therapy.

For patients with oncological diseases complicated by metastases, the instructions for use recommend a dosage - 1 suppository of Imunofan 10 days before the start of chemotherapy and throughout the entire subsequent period of treatment.

Children with malignant neoplasms prescribe 1 suppository of the drug for a course of 20-30 days. This helps to avoid toxicosis after radiation or chemotherapy.

With papilloma viral infection in children and adults appoint 1 suppository Imunofan per day. According to the instructions, the course of therapy is 10 days.

With cytomegalovirus, herpes, toxoplasmosis, chlamydia, 1 suppository is prescribed 1 time per day. The duration of the course is 10 days.

With immunodeficiency, patients are prescribed 1 suppository daily for 20 days. After that, they take a break for 2 weeks, then spend another course.

For viral hepatitis, 1 suppository Imunofan is prescribed once a day for 20 days. In order to prevent recurrence of the disease, the course of therapy is repeated after 2 months.

In septic conditions in surgical patients, 1 suppository of the drug is prescribed 1 time per day. The duration of the course of treatment is 15 days.

Spray Imunofan

The use of the spray in acute and chronic infectious and inflammatory diseases with symptoms of intoxication and immunodeficiency is carried out as part of complex therapy daily, 1 dose in each nasal passage 2 times a day, for 10-15 days.

Side effects

The instruction warns of the possibility of developing the following side effects when prescribing Imunofan:

• Allergic reactions to the components of the drug.

As a result of the activation of phagocytosis, a short-term exacerbation of foci of chronic inflammation, supported by the persistence of viral or bacterial antigens, is possible.

Contraindications

It is contraindicated to prescribe Imunofan in the following cases:

• pregnancy complicated by Rhesus conflict;
• children's age up to 2 years;
• hypersensitivity to the components of the drug.

Overdose

There are no data on drug overdose.

Imunofan analogues, price in pharmacies

If necessary, you can replace Imunofan with an analogue according to therapeutic effect are the drugs:

1. Alkimer,
2. Groprinosin,
3. IRS 19,

When choosing analogues, it is important to understand that the instructions for use of Imunofan, price and reviews, do not apply to drugs of similar action. It is important to consult a doctor and not to make an independent replacement of the drug.

Price in Russian pharmacies: Imunofan 100mcg 5 suppositories - from 478 to 562 rubles, the price of a solution of Imunofan 50 mcg / ml 1 ml 5 pcs. - from 497 to 620 rubles, the cost of the spray - from 926 rubles, according to 402 pharmacies.

Store in a dry, dark place at a temperature of 2 to 10 °C. Keep away from children. Shelf life - 2 years.

Conditions for dispensing from pharmacies - by prescription.